Kyuss (pronounced /ˈkaɪəs/ KAI-us) was an influential American stoner metal band, originally from Palm Desert, California. After forming in the late 1980s and releasing an EP under the name Sons of Kyuss in 1990, the band shortened its name to Kyuss. Over the next five years the band released four full-length albums before splitting up in 1995.

The band's only continuous members were vocalist John Garcia and guitarist Josh Homme, but also featured Brant Bjork, Scott Reeder, Alfredo Hernandez, Chris Cockrell, and Nick Oliveri. Since then, members of Kyuss have gone on to form or play in several notable bands including Queens of the Stone Age, Fu Manchu, Unida, Brant Bjork, Eagles of Death Metal, Mondo Generator, Hermano, Slo Burn and Them Crooked Vultures.