Sam Bell has a three year contract to work for Lunar Industries. For the contract's entire duration, he is the sole employee based at their lunar station. His primary job responsibility is to harvest and periodically rocket back to Earth supplies of helium-3, the current clean and abundant fuel used on Earth. There is no direct communication link available between the lunar station and Earth, so his only direct real-time interaction is with GERTY, the intelligent computer whose function is to attend to his day to day needs.

For their honeymoon, newlyweds Cliff and Cydney head to the tropical islands of Hawaii. While journeying through the paradisaical countryside the couple encounters Kale and Cleo, two disgruntled hitchhikers and Nick and Gina, two wild but well-meaning spirits who help guide them through the lush jungles. The picturesque waterfalls and scenic mountainsides quickly give way to terror when Cliff and Cydney learn of a grisly murder that occurred nearby and realize that they're being followed by chance acquaintances that suspiciously fit the description of the killers.